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Relevant publications mentioning your query species (Methanosaeta concilii):

(none).

Relevant publications mentioning other organisms:

  • Identification of essential and non-essential single-stranded DNA-binding proteins in a model archaeal organism.
    Skowyra A, MacNeill SA
    Nucleic Acids Res. 40(3):1077-90 (2012).
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  • Abstract:
    Identification of essential and non-essential single-stranded DNA-binding proteins in a model archaeal organism Agnieszka Skowyra and Stuart A. MacNeill* School of Biology, University of St Andrews, North Haugh, St Andrews, Fife KY16 9TF, UK ABSTRACT Single-stranded DNA-binding proteins (SSBs) play vital roles in all aspects of DNA metabolism in all three domains of life and are characterized by the presence of one or more OB fold ssDNA-binding domains. Here, using the genetically tractable euryarchaeon Haloferax volcanii as a model, we present the first genetic analysis of SSB function in the archaea. We show that genes encoding the OB fold and zinc finger-containing RpaA1 and RpaB1 proteins are individually non-essential for cell viability but share an essential function, whereas the gene encoding the triple OB fold RpaC protein is essential. Loss of RpaC function can however be rescued by elevated expression of RpaB, indicative of functional overlap between the two classes of haloarchaeal SSB. Deletion analysis is used to demonstrate important roles for individual OB folds in RpaC and to show that conserved N- and C-terminal domains are required for efficient repair of DNA damage. Consistent with a role for RpaC in DNA repair, elevated expression of this protein leads to enhanced resistance to DNA damage. Taken together, our results offer important insights into archaeal SSB function and establish the haloarchaea as a valuable model for further studies. INTRODUCTION Single-stranded DNA-binding proteins (SSBs) are indispensable for many aspects of DNA metabolism including replication, repair and recombination, and play a vital role in the maintenance of genomic stability in all three domains of life (1,2). SSBs are characterized by the presence of one or more OB (oligosaccharide oligonucleotide binding) fold domains. OB folds consist of a ?ve-stranded b-sheet that is coiled to form a closed b-barrel, often capped by an a-helix (2,3). They range in length from 75 1...
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[showing publications for 'endA' only]
Browse textmining interactions in tabular form:
node1node2node1 accessionnode2 accessionnode1 annotationnode2 annotationtextmin. score
MCON_0721MCON_2842MCON_0721MCON_2842
Hypothetical protein
OB-fold nucleic acid binding domain-containing protein
0.73
MCON_0721rpaMCON_0721MCON_1551
Hypothetical protein
Single-stranded DNA-binding replication protein A
0.73
MCON_1549rpaMCON_1549MCON_1551
AsnC family transcriptional regulator
Single-stranded DNA-binding replication protein A
0.83
MCON_1550MCON_1952MCON_1550MCON_1952
Hypothetical protein
Ser/Thr protein phosphatase family protein
0.287
MCON_1550MCON_2842MCON_1550MCON_2842
Hypothetical protein
OB-fold nucleic acid binding domain-containing protein
0.297
MCON_1550endAMCON_1550MCON_2907
Hypothetical protein
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
0.165
MCON_1550rpaMCON_1550MCON_1551
Hypothetical protein
Single-stranded DNA-binding replication protein A
0.407
MCON_1952MCON_1550MCON_1952MCON_1550
Ser/Thr protein phosphatase family protein
Hypothetical protein
0.287
MCON_1952MCON_2842MCON_1952MCON_2842
Ser/Thr protein phosphatase family protein
OB-fold nucleic acid binding domain-containing protein
0.151
MCON_1952endAMCON_1952MCON_2907
Ser/Thr protein phosphatase family protein
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
0.44
MCON_1952rpaMCON_1952MCON_1551
Ser/Thr protein phosphatase family protein
Single-stranded DNA-binding replication protein A
0.257
MCON_2842MCON_0721MCON_2842MCON_0721
OB-fold nucleic acid binding domain-containing protein
Hypothetical protein
0.73
MCON_2842MCON_1550MCON_2842MCON_1550
OB-fold nucleic acid binding domain-containing protein
Hypothetical protein
0.297
MCON_2842MCON_1952MCON_2842MCON_1952
OB-fold nucleic acid binding domain-containing protein
Ser/Thr protein phosphatase family protein
0.151
MCON_2842endAMCON_2842MCON_2907
OB-fold nucleic acid binding domain-containing protein
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
0.259
MCON_2842rpaMCON_2842MCON_1551
OB-fold nucleic acid binding domain-containing protein
Single-stranded DNA-binding replication protein A
0.270
MCON_2842top6AMCON_2842MCON_1547
OB-fold nucleic acid binding domain-containing protein
DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity
0.119
endAMCON_1550MCON_2907MCON_1550
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
Hypothetical protein
0.165
endAMCON_1952MCON_2907MCON_1952
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
Ser/Thr protein phosphatase family protein
0.44
endAMCON_2842MCON_2907MCON_2842
tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp
OB-fold nucleic acid binding domain-containing protein
0.259
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