MCON_1550 protein (Methanosaeta concilii)

Nodes and Egdes

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Network nodes represent host and virus proteins

Splice isoforms or post-translational modifications are collapsed, i.e. each host node represents all the proteins produced by a single, protein-coding gene locus. Virus nodes represent polyprotein cleavage products if the viral locus is polycistronic.

Edges represent protein-protein associations

Associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

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[Homology]

Score

Proteins: MCON_1550

Predicted Functional Partners:

rpa

0.984

MCON_2842

0.851

MCON_1952

0.815

top6A

0.779

MCON_1545

0.774

top6B

0.752

MCON_1549

0.751

endA

0.671

MCON_1060

0.660

MCON_0721

0.659

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TSV: tab separated values - can be opened in Excel

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structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

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a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

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MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCON_0721	MCON_1060	MCON_0721	MCON_1060	Hypothetical protein	Hypothetical protein	0.651
MCON_0721	MCON_1545	MCON_0721	MCON_1545	Hypothetical protein	Hypothetical protein	0.599
MCON_0721	MCON_1550	MCON_0721	MCON_1550	Hypothetical protein	Hypothetical protein	0.659
MCON_0721	MCON_1952	MCON_0721	MCON_1952	Hypothetical protein	Ser/Thr protein phosphatase family protein	0.553
MCON_0721	MCON_2842	MCON_0721	MCON_2842	Hypothetical protein	OB-fold nucleic acid binding domain-containing protein	0.645
MCON_0721	endA	MCON_0721	MCON_2907	Hypothetical protein	tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	0.609
MCON_0721	pcn	MCON_0721	MCON_1510	Hypothetical protein	DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	0.627
MCON_0721	priL	MCON_0721	MCON_1508	Hypothetical protein	DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	0.599
MCON_0721	priS	MCON_0721	MCON_1623	Hypothetical protein	DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]	0.629
MCON_0721	rpa	MCON_0721	MCON_1551	Hypothetical protein	Single-stranded DNA-binding replication protein A	0.670
MCON_0721	top6A	MCON_0721	MCON_1547	Hypothetical protein	DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity	0.463
MCON_1060	MCON_0721	MCON_1060	MCON_0721	Hypothetical protein	Hypothetical protein	0.651
MCON_1060	MCON_1545	MCON_1060	MCON_1545	Hypothetical protein	Hypothetical protein	0.631
MCON_1060	MCON_1550	MCON_1060	MCON_1550	Hypothetical protein	Hypothetical protein	0.660
MCON_1060	endA	MCON_1060	MCON_2907	Hypothetical protein	tRNA-splicing endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5’ and 3’ splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’ cyclic phosphate and 5’-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	0.477
MCON_1060	pcn	MCON_1060	MCON_1510	Hypothetical protein	DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	0.619
MCON_1060	priL	MCON_1060	MCON_1508	Hypothetical protein	DNA primase, large subunit; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	0.624
MCON_1060	priS	MCON_1060	MCON_1623	Hypothetical protein	DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]	0.639
MCON_1060	rpa	MCON_1060	MCON_1551	Hypothetical protein	Single-stranded DNA-binding replication protein A	0.660
MCON_1060	top6A	MCON_1060	MCON_1547	Hypothetical protein	DNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity	0.446

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